This chapter examines efforts to solve food, nutrition, and farming challenges in the global agrifood system, highlighting the global failure to meet the UN’s Sustainable Development Goals (SDGs) to curb climate change amid increasing food insecurity, hunger, and diet-related diseases.  It discusses local, national, and global approaches, including fortification and biofortification (genetic engineering); policy and regulation; nutrition programs and education; and diet guidelines and recommendations.  It defines the principles of healthy, sustainable diets, noting agroecology, regenerative agriculture, and technological advances (e.g., precision agriculture, artificial intelligence (AI), nanotechnology, robots, drones, and the Internet of Things (IoT)) that have transformed farming in the Fourth Industrial (Agricultural) Revolution (4AR).  The chapter explores food waste solutions, emphasizing the reduce-reuse-recycle framework within a circular economy that feeds hungry people.  Finally, it stresses the importance of an ecotechno future and multilevel interventions, local to global, to create healthy, sustainable food systems that shift sapiens as a species to plant-based diets.